OvRx Sanford Guide

OvRx generates reports and a Sanford Guide section that contain aspects of the Sanford Guide. Sanford Guide is a tool used by medical providers, physicians, and pharmacists as a diagnostic and therapeutic aid. The tool provides reference information covering bacterial, viral, and fungal pathogens. The tool also includes antimicrobial therapy properties.

There are two locations Sanford Guide components can be found: on the report itself and in the OvDx Portal under the Sanford Guide tab.This guide covers the components of the Sanford Guide information displayed in the two locations. Individual sections of this guide are shown below. Read the whole guide or skip to the section you need.

Sanford Guide Components

Sanford Guide OvDx Portal features

Sanford Guide Components

Antimicrobial Therapy Legend

The Antimicrobial Therapy Key is displayed below. It contains the rankings used for all antimicrobial therapies. There are 4 ranking options from highest to lowest. Each symbol corresponds to a number of points. The points become important when listing antimicrobial therapies for effectiveness against all the positive pathogens detected in the panel.

Detected Pathogen List

Detected Pathogens from the test panel are listed and numbered beneath the Antimicrobial Therapy Legend. The number next to the pathogen matches the Therapy Table. For example, pathogen 1 is Candida albicans. Therefore, row 1 in the therapy table shows the therapy recommendations for Candida albicans. In the example below, Amphotericin B is one green + for Candida albicans

Detected Pathogens without Sanford Therapies

Pathogens detected in the panel that are not included in the therapy table are listed under the Detected Pathogens without Sanford Therapies section of the report. 

Note: The Sanford Guide has numerous entries and therapy recommendations for viral, fungal, and bacterial agents. Rarely, some pathogens have a Sanford entry, but no listed therapy recommendations. Even more rarely, some pathogens will not have a Sanford entry. This field does not display if all pathogens have therapy recommendations. It is possible that a broader category could provide therapy recommendations for your pathogen of interest (for example, the Proteus species Sanford entry can provide therapy recommendations for Proteus mirabilis). For questions about this section and linking the appropriate Sanford entry to your pathogen(s) of interest, contact success@ovation.io.

Detected Resistance Genes

Detected Antibiotic Resistance Genes from the test panel are redisplayed below Detected Pathogens on the report. Antibiotic Class and a Description are also listed.

Note: Resistance Gene class and descriptions are provided by the laboratory. Laboratories can customize the classes and descriptions to best meet the needs of their providers. For example, labs can use descriptions to help their providers deduce which classes of therapies in the therapy table to avoid if that resistance gene is detected. 

Antimicrobial Therapy Table

A table is generated using the Sanford Guide entries, therapy recommendations within the Sanford entries, and the detected pathogens in the panel. The panel orders therapies by their combined total points. The numbers at the top of the table match the numbered list of detected pathogens.

The Antimicrobial Therapy Table DOES NOT consider resistance genes when ordering therapies because Sanford does not provide therapy recommendations based on resistance genes. The user can examine the antibiotic class of detected resistance genes and compare that to the therapy classes in the Antimicrobial Therapy Table to deduce which therapies are best to recommend.

The Antimicrobial Therapy Table is best used as a diagnostic reference aid to assist providers in their consideration of therapies. OvRx does not replace a licensed provider or pharmacist. The provider or pharmacist’s expertise is still required to make any therapy recommendations to patients. 

Note: If multiple therapies have the same total points, then the therapies are listed alphabetically. Be sure to review all recommended therapies and consider any detected resistance genes when providing recommendations. 

Disclaimers

The disclaimers field comes at the end of the report and contains the required Sanford Guide disclaimers. 

Tip: Additional laboratory-specific disclaimers can be added to your report. If you would like additional disclaimers displayed, contact success@ovation.io.

Sanford Guide OvDx Portal Features

The Sanford Guide entries for pathogens and therapies can be accessed directly in the OvDx Portal. OvDx Portal users can go to the Sanford Guide tab under their individual orders to access the Sanford Guide entries. Below are the instructions for OvDx Portal users to navigate to the Sanford Guide tab, and how to access the Sanford Entries.

Navigating to the Sanford Guide Tab

1.  Log in to the OvDx Portal and click on a completed report’s sample ID

Tip: Samples with completed reports have a green download icon next to the sample ID

2.  Click Reports on the Order Summary Page

3.  Click on the green report name to display the PDF of the report

4.  Click on the green Sanford Guide tab to access and interact with Sanford Guide entries for pathogens and therapies

5.  The contents of the report are re-displayed on this page

Sanford Guide Pathogen Entries

Clicking the pathogen name opens a new window with the Sanford entry. 

The Sanford entry contains clinical setting info, classification, primary regimen, alternative regimen, and comments

Scroll down to see more of the window contents. Click the X in the top right corner to close the window and return to the Sanford Guide tab.

Sanford Guide Therapy Entries

Clicking the therapy name opens a new window with the Sanford entry. 

The Sanford entry contains:

  • Usage and dosing
  • Adult dose
  • Pediatric dose
  • Renal adjustment
  • Hepatic adjustment
  • Other adjustments
  • Adverse effects
  • Antimicrobial spectrum
  • Pharmacology
  • Major drug interactions
  • Comments

Scroll down to see more of the window contents. Click the X in the top right corner to close the window and return to the Sanford Guide tab.

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